Biphenylalanine

Biphenylalanine is an unnatural (non-standard) hydrophobic amino acid that serves as a crucial building block in the design and synthesis of various peptides and small molecules with therapeutic potential. Its incorporation often enhances properties such as cellular uptake, membrane interaction, and specific binding affinities. It has been utilized in the development of antimicrobial peptides, inhibitors for enzymes like plasmin and histone demethylase KDM4A, antagonists for integrins, and components for targeting cancer cells and cardiomyocytes. Additionally, it plays a significant role in genetic code expansion technologies, allowing for the site-specific incorporation of non-standard amino acids into proteins for research and biomanufacturing applications.

Other names

l-biphenylalanine4,4-L-biphenylalanine(2'-Et, 4'-OMe)4, 4'-L-biphenylalanine