biphenylindanone A

Biphenylindanone A (BINA) is a potent and selective positive allosteric modulator (PAM) of the metabotropic glutamate receptor 2 (mGluR2). It functions by binding to an allosteric site on the receptor, thereby enhancing the receptor's response to its endogenous ligand, glutamate, without activating the receptor independently. BINA has been extensively utilized as a pharmacological tool in preclinical research to investigate the role of mGluR2 in various central nervous system disorders. Studies have demonstrated its potential in reducing symptoms of schizophrenia, anxiety, and L-DOPA-induced dyskinesia and psychosis-like behaviors in Parkinson's disease models. Its high selectivity for mGluR2 over other metabotropic glutamate receptor subtypes makes it a valuable compound for studying glutamatergic modulation.

Other names

3'-(2-benzocyclopentanonyl)-biphenyl-4-carbonitrile3'-(2-oxocyclopentyl)[1,1'-biphenyl]-4-carbonitrile