Drug intelligence / Profile preview

birch pollen allergen extract

Development stage
Phase 3
Lead developer
ALK Abelló
Modality
Sublingual Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics, Subcutaneous Immunotherapy → Allergy Immunotherapy → Therapeutic Vaccines → Vaccines & Immunotherapeutics
Administration
Subcutaneous, Sublingual
01

Overview

Birch pollen allergen extract is a standardized biologic preparation derived from the pollens of the birch tree (Betula species), primarily used for allergy immunotherapy in individuals with moderate to severe allergic rhinitis or rhinoconjunctivitis caused by exposure to birch and related tree pollens (alder, hazel, oak). The mechanism of action involves gradual desensitization of the immune system through controlled exposure to small amounts of the relevant allergens. This can be administered as sublingual tablets (SLIT) or via injection as part of immunotherapy regimens. Over time, this leads to reduced sensitivity and symptoms upon natural exposure. Birch pollen extracts are also used in allergy testing (skin prick tests). Clinical trials have demonstrated efficacy in reducing both symptoms and medication use during tree-pollen seasons[3][4][6][8][9].

Brand names
ITULATEKSQ tree SLIT-tablet
Other names
white birch allergen extractsilver birch pollenEuropean white birch pollenweeping birch pollen
02

Targets

IgE (Immunoglobulin E)

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