Bis(5-Amidino-2-Benzimidazolyl)Methanone

Bis(5-Amidino-2-Benzimidazolyl)Methanone is an experimental small molecule compound with the molecular formula C17H14N8O and a molecular weight of approximately 346.3 g/mol[1][2][8]. It belongs to the class of aromatic diamidines and features two benzimidazole rings connected via a methanone (carbonyl) bridge. The compound has been studied primarily as an inhibitor of serine proteases, including tryptase and trypsin[4][10]. Its mechanism involves competitive inhibition at the active site of these enzymes, making it a potential lead for developing anticoagulant or anti-inflammatory agents[4][10]. However, there are no approved indications or advanced clinical trials for this molecule as of now; its use remains experimental.

Other names

2-(5-carbamimidoyl-1H-1,3-benzodiazole-2-carbonyl)-1H-1,3-benzodiazole-6-carboximidamide2,2'-carbonylbis(1h-benzimidazole-6-carboximidamide)SCHEMBL4314492SCHEMBL-4314492SCHEMBL 4314492SCHEMBL21067335SCHEMBL-21067335SCHEMBL 21067335AHIBAO