Drug intelligence / Profile preview

bismuth subcitrate potassium

Development stage
Unknown
Lead developer
Royal DSM
Modality
Small Molecules
Administration
Oral
01

Overview

Bismuth subcitrate potassium (marketed under the brand name Bismanthin by Aani Darman) is a colloidal bismuth salt used primarily in combination with antibiotics (such as metronidazole and tetracycline) and a proton pump inhibitor (such as omeprazole) for the eradication of *Helicobacter pylori* infections and the treatment of peptic ulcer disease. It acts locally in the stomach by forming a protective, acid-resistant coating over the ulcerated mucosa, stimulating mucosal prostaglandin and bicarbonate secretion, and exerting direct bactericidal effects against *H. pylori*. It disrupts bacterial cell walls and inhibits key bacterial enzymes, including the ATP-dependent Clp protease ATP-binding subunit ClpX.

Brand names
BisaminBismantinBismanthinBismobandBismonolBismutanDe-NolDe-NoltabTrymoVis-Nol
Other names
bismuth subcitratebismuth tripotassium dicitratecolloidal bismuth subcitratetripotassium dicitratobismuthate
02

Targets

ClpX (Caseinolytic mitochondrial matrix peptidase chaperone subunit X)

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