bisoprolol

Bisoprolol is a highly selective β1-adrenergic receptor blocker (beta-blocker) used primarily for the treatment of hypertension, angina pectoris (coronary heart disease/angina), certain arrhythmias (such as rapid supraventricular arrhythmias and ventricular premature beats), and chronic stable heart failure with reduced ejection fraction. It has no intrinsic sympathomimetic activity or membrane-stabilizing effect. Bisoprolol exhibits a high affinity for β1 receptors—11 to 34 times greater than for β2 receptors—and its selectivity is about four times that of atenolol. The drug has a long duration of action (>24 hours), minimal respiratory side effects at therapeutic doses, and does not significantly affect lipid metabolism. It is well absorbed orally with high bioavailability (~90%), low first-pass effect (<10%), peak plasma concentration in 1.7–3 hours, and an elimination half-life of about 10 hours[2][5][6].

Brand names

博苏山益新

Other names

富马酸比索洛尔bisoprolol fumarate