bisoprolol + perindopril + amlodipine

bisoprolol + perindopril + amlodipine is a fixed-dose triple combination (FDC) therapy developed by Servier for the treatment of hypertension, particularly in patients whose blood pressure is not adequately controlled by dual therapy. The combination integrates three antihypertensive agents with complementary mechanisms: **perindopril**, an angiotensin-converting enzyme (ACE) inhibitor that reduces systemic vascular resistance; **amlodipine**, a dihydropyridine calcium channel blocker (CCB) that induces peripheral vasodilation; and **bisoprolol**, a selective beta-1 adrenergic receptor blocker that reduces heart rate and cardiac output. By targeting the renin-angiotensin-aldosterone system, calcium-mediated vasoconstriction, and sympathetic activity simultaneously, the therapy provides robust blood pressure control. It is formulated as a single-pill (capsule) to reduce pill burden and improve patient adherence.

Brand names

Tri-Cosyrel

Other names

bisoprolol fumarate + perindopril arginine + amlodipine besylateperindopril arginine/amlodipine/bisoprolol fumarate