bivalent influenza virus split vaccine

The bivalent influenza virus split vaccine is an inactivated vaccine developed by the Shandong Provincial Center for Disease Control and Prevention, designed to provide protection against two specific strains of the influenza virus, typically Influenza A subtypes H1N1 and H3N2. As a split-virion vaccine, it is produced by disrupting the virus particles with detergents or solvents, which reduces reactogenicity while maintaining the immunogenicity of the surface antigens, primarily hemagglutinin (HA) and neuraminidase (NA). The vaccine works by inducing the production of neutralizing antibodies that target the HA protein, preventing the virus from attaching to and entering host respiratory cells. This specific bivalent formulation has been evaluated in clinical trials to assess its safety and immunogenicity across various age groups, particularly in the context of seasonal influenza prevention in China.

Other names

bivalent influenza split vaccinebivalent influenza vaccineH1N1+H3N2 bivalent split vaccine