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BIWH 3
- Development stage
- Discontinued
- Lead developer
- Boehringer Ingelheim
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intravenous
01
Overview
BIWH 3 is a recombinant form of human monocyte chemotactic protein-1 (MCP-1), specifically the pyroglutamate-modified version (pyro-Glu MCP-1). It was developed as a biologic agent to study its pharmacokinetics and pharmacodynamics in humans. The drug was investigated for its effects on plasma levels of MCP-1 and markers of leukocyte, coagulation, platelet, and endothelial activation. Its primary clinical development focused on patients with severe peripheral arterial occlusive disease (PAOD) and chronic critical limb ischemia (CLI), aiming to assess safety following intraarterial infusion. The mechanism involves modulation of immune cell trafficking via the chemokine receptor pathway; however, detailed molecular targets beyond MCP-1 activity are not specified in available sources[1].
- Other names
- recombinant human pyro-Glu MCP-1pyro-Glu-rhMCP-1pyro-Glu-rhMCP1pyro-Glu-rhMCP 1
02
Targets
CCL2 (C-C motif chemokine 2)
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