Drug intelligence / Profile preview

BK002

Development stage
Preclinical
Lead developer
Biokuris
Modality
Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration
Oral
01

Overview

**BK002** is an oral, fixed-dose synbiotic medical-nutrition product developed by BiOkuris for dietary management of **irritable bowel syndrome**, including constipation-predominant, diarrhea-predominant, and mixed-subtype disease. The formulation combines fungal chitin-glucan, *Lactobacillus acidophilus* NCFM, and vitamin D3. It is intended to support microbiota balance and intestinal-barrier function and to reduce gastrointestinal symptoms through a gut-brain-axis-oriented, multi-component approach. BiOkuris reported positive results from its 14-week randomized Vitabiotic study and has described BK002 as ready for licensing and distribution; it is not presented as an approved pharmaceutical medicine.

02

Targets

SRD5A (Steroid 5-alpha-reductase)CD274 (Programmed cell death protein 1 ligand 1)DICER1 (Dicer ribonuclease III)DNMT1 (DNA (cytosine-5)-methyltransferase 1)VDR (Vitamin D receptor)CYP17A1 (Steroid 17-alpha-hydroxylase/C17,20 lyase)PDCD1 (Programmed cell death protein 1 receptor)

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