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BKR-013

Development stage: Unknown
Lead developer: BioKier
Modality: Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Drug Delivery Systems
Administration: Oral

Overview

BKR-013 is a proprietary, colon-targeted, sustained-release oral formulation of L-glutamine developed by BioKier for the treatment of metabolic diseases, particularly type 2 diabetes. The drug is designed to mimic the beneficial effects of metabolic surgery on glucose metabolism and cardiometabolic health without surgical intervention. Its mechanism involves stimulating L-cells in the lower gut to increase secretion of endogenous gut hormones such as GLP-1, PYY, GLP-2, and oxyntomodulin—hormones that regulate glucose metabolism, lipid levels, and appetite. This approach aims to correct deficiencies in these hormones observed in diabetes and obesity. BKR-013 has been evaluated in clinical trials for its effect on average daily glucose levels in patients with type 2 diabetes[1][2][3][4][7][8].

Other names: L-glutamine - BioKier

Targets

CaSR (Extracellular calcium-sensing receptor)SNAT2 (Sodium-coupled neutral amino acid transporter 2)GPRC6A (G protein-coupled receptor class C group 6 member A)

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