Drug intelligence / Profile preview

BKT130

Development stage
Preclinical
Lead developer
Biokine Therapeutics
Modality
Peptides
Administration
Ophthalmic
01

Overview

BKT130 is a broad-spectrum, promiscuous chemokine receptor antagonist being developed by Biokine Therapeutics for the treatment of age-related macular degeneration (AMD). Unlike selective antagonists that target a single receptor, BKT130 is designed to block multiple chemokine-driven pathways simultaneously, addressing the complex inflammatory and angiogenic environment characteristic of AMD. By inhibiting a range of chemokine receptors, the drug aims to reduce the infiltration of inflammatory cells and the formation of pathological new blood vessels in the retina. It is currently in the preclinical stage of development and is part of Biokine's platform of chemokine-derived peptides.

02

Targets

CXCL11 (C-X-C motif chemokine ligand 11)CXCL9 (C-X-C motif chemokine ligand 9)CCL2 (C-C motif chemokine 2)CCL5 (C-C Motif Chemokine Ligand 5)CXCL12 (C-X-C motif chemokine ligand 12)CXCL10 (C-X-C Motif Chemokine Ligand 10)

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