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BL-002
- Development stage
- Preclinical
- Lead developer
- Bloom Science
- Modality
- Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
BL-002 is a preclinical-stage therapeutic candidate being developed by Bloom Science for the treatment of Amyotrophic Lateral Sclerosis (ALS). The drug is designed to modulate cellular bioenergetics, addressing the metabolic deficits and mitochondrial dysfunction that are characteristic of ALS pathology. Developed using Bloom Science's proprietary IrisRx platform, which identifies neuroactive microbes and metabolites within the gut-brain axis, BL-002 aims to provide neuroprotection by optimizing energy metabolism in motor neurons. As a microbiome-based therapy, it represents a novel approach to treating neurodegenerative diseases by leveraging the systemic influence of the gut microbiota on central nervous system health.
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