Drug intelligence / Profile preview

black seed oil

Development stage
Phase 3
Modality
Small Molecules
Administration
Oral, Topical
01

Overview

Black seed oil is an herbal extract derived from the seeds of Nigella sativa, a flowering plant native to regions such as Eastern Europe, Northern Africa, and Southwestern Asia. The primary bioactive compound in black seed oil is thymoquinone, which has demonstrated anti-inflammatory, antioxidant, antibacterial, antifungal, antiviral, and immunomodulatory properties. Black seed oil has been used for centuries in traditional medicine for a variety of conditions. Modern research suggests potential benefits in reducing inflammation (including neuroinflammation), supporting immune function, lowering blood sugar levels (potentially aiding diabetes management), improving skin conditions (such as acne and vitiligo), relieving symptoms of asthma and allergies through bronchodilation and antihistaminic effects, supporting weight loss by appetite suppression or metabolic effects, lowering blood pressure slightly in some studies, providing hepatoprotective effects for liver health, promoting wound healing and hair health when applied topically or ingested. It is available as an oral supplement (oil or capsule) or topical preparation[1][2][3][4][5][6][7][8].

Brand names
Nigellin
Other names
black cumin oilkalonji oilnigella sativa oilblack caraway oil
02

Targets

NFE2L2 (Nuclear factor (erythroid-derived 2)-like 2)

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