blattella germanica allergenic extract

Blattella germanica allergenic extract is a biological product derived from the German cockroach, used for both diagnosing and treating cockroach allergies. As a diagnostic, it is used in skin prick tests and nasal allergen challenges (NAC) to confirm sensitization. As a therapeutic, it is being investigated as an allergen-specific immunotherapy, primarily through subcutaneous injections (SCIT), to treat allergic conditions like asthma and perennial allergic rhinitis, particularly in urban children. The extract contains multiple allergens, including the major allergens Bla g 1 and Bla g 2, which trigger IgE-mediated responses in sensitized individuals. The goal of immunotherapy with this extract is to induce immune tolerance by modulating the body's response, which involves shifting from a Th2-driven allergic reaction to a more tolerant state, characterized by the production of blocking IgG antibodies and a reduction in inflammatory cytokines. The National Institute of Allergy and Infectious Diseases (NIAID) and the Inner City Asthma Consortium (ICAC) have sponsored several clinical trials to evaluate its efficacy and safety.

Other names

German cockroach allergenic extractcockroach extract