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bleomycin + etoposide + doxorubicin + cyclophosphamide + vincristine + dacarbazine + prednisolone
- Development stage
- Unknown
- Modality
- Small Molecules
- Administration
- Intravenous, Oral
01
Overview
BEACOPP-DAC (also referred to as BEACOPDac) is a multi-agent chemotherapy regimen primarily utilized for the treatment of classic Hodgkin lymphoma. It is a modified variant of the standard BEACOPP protocol, where the alkylating agent procarbazine is replaced with dacarbazine. This substitution is intended to reduce long-term toxicities, specifically lowering the risk of secondary malignancies and preserving fertility, while maintaining comparable efficacy to the original regimen. The protocol consists of bleomycin, etoposide, doxorubicin (Adriamycin), cyclophosphamide, vincristine (Oncovin), dacarbazine, and prednisolone. It is often administered in an escalated dose format (escalated BEACOPDac) for high-risk patients or those showing inadequate response on interim PET imaging. The regimen works through multiple mechanisms, including DNA alkylation, intercalation, topoisomerase II inhibition, and microtubule disruption.
- Other names
- BEACOPDacBEACOP-DAC
02
Targets
TUBB (Tubulin (alpha and beta subunits))TOP2A (DNA topoisomerase II)GR (Glucocorticoid receptor)DNA
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