bleomycin A2

Bleomycin A2 is a glycopeptide antibiotic produced by Streptomyces verticillus and is the primary constituent of clinical bleomycin formulations used as an antineoplastic agent, especially for solid tumors and lymphomas[1][2][3][7]. It exerts its effect mainly through inhibition of DNA synthesis, causing single- and double-strand breaks via DNA cleavage facilitated by oxygen and metal ions (primarily iron)[1][3][5]. This results in cell cycle arrest at the G2 and M phases[1][3][5]. Bleomycin A2 is commonly formulated together with bleomycin B2 in commercial products but is the representative species responsible for clinical effects[1][4]. Its principal indications include Hodgkin's lymphoma, non-Hodgkin's lymphoma, testicular carcinoma, and squamous cell carcinomas[6][7]. It is also used as a sclerosing agent for malignant pleural effusions[5].

Brand names

BlenamaxBleomycin HexalBleoginBleolemBleocellBleo-cellBlanoxan

Other names

11116-31-7BleomycinsBleomycin A(2)Bleomycin sulfateBleomycinum Mack