bm-mesenchymal stem cell-derived extracellular vesicles

BM-MSC-EVs are **extracellular vesicles** (EVs), including exosomes and microvesicles, derived from **bone marrow mesenchymal stem cells (BM-MSCs)**. They contain biologically active molecules such as proteins, lipids, mRNAs, and microRNAs from the parent BM-MSCs, and are involved in intercellular signaling and modulation of the immune response. BM-MSC-EVs mimic many of the biological functions of their parent MSCs and possess **immunomodulatory, anti-inflammatory, regenerative, and tissue-protective properties**. Mechanistically, they influence target cells by delivering their cargo, modulating apoptosis, proliferation, and immune cell activity. Therapeutic indications are being investigated in a range of diseases, including graft-versus-host disease (GVHD), cardiovascular diseases, inflammatory conditions, COVID-19, musculoskeletal regeneration, and possibly leukemia. Their cell-free nature allows them to overcome some limitations of cell-based therapies, such as immunogenicity and tumorigenicity; however, clinical standardization and regulatory pathways remain under development[1][2][3][4][6][9].

Other names

bone marrow mesenchymal stem cell extracellular vesiclesbone marrow MSC-EVsbone marrow MSC-derived exosomes