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BMC-127
- Development stage
- Preclinical
- Lead developer
- Biomica
- Modality
- Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics
- Administration
- Oral
01
Overview
BMC-127 is a **live biotherapeutic product** and rationally designed **microbial consortium** being developed by Biomica for immuno-oncology. It is intended to modulate the **gut microbiome** to enhance anti-tumor immune activity and improve patient responsiveness to **immune checkpoint blockade**, including **PD-1 and PD-L1 inhibitor** therapies. Publicly described development has focused on cancers such as **non-small cell lung cancer** and **renal cell carcinoma**, with the program reported to be in **preclinical development** as part of Biomica's oncology pipeline.
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