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BMC333

Development stage: Preclinical
Lead developer: Biomica
Modality: Synthetic Biology Platforms → Engineered Microbial Therapeutics → Microbiome Therapeutics, Fresh FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Yeast Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Bacterial Strains → Single Strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Defined Consortia → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics, Frozen FMT → Fecal Microbiota Transplantation (FMT) → Microbiome Therapeutics, Genetically Modified Bacteria → Engineered Microbial Therapeutics → Microbiome Therapeutics, Microbial Metabolites → Microbiome-Derived Products → Microbiome Therapeutics, Microbial Proteins → Microbiome-Derived Products → Microbiome Therapeutics, Complex Communities → Multi-strain Products → Live Biotherapeutic Products → Microbiome Therapeutics
Administration: Oral

Overview

**BMC333** is Biomica's rationally designed, four-strain live bacterial consortium being developed as a microbiome-based therapeutic for inflammatory bowel disease. The live biotherapeutic product was optimized from strains previously included in Biomica's BMC321 and BMC322 candidates and was selected for complementary anti-inflammatory functions. In preclinical colitis models, BMC333 reduced intestinal inflammatory damage and inflammatory biomarkers; reported findings also included increased immunosuppressive cell populations in the intestinal lamina propria without increased interferon-gamma production. Biomica completed preclinical development and had been scaling GMP manufacturing toward a planned Phase 1 study. ([evogene.com](https://evogene.com/newsroom/press-release/biomica-reports-positive-results-from-pre-clinical-studies-in-its-inflammatory-bowel-disease-ibd-program/))

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