BMS-604992

BMS-604992 (also known as EX-1314) is a potent, selective, and orally bioactive small molecule agonist of the growth hormone secretagogue receptor (GHSR), also known as the ghrelin receptor. Developed by Bristol Myers Squibb, the compound exhibits high binding affinity (Ki = 2.3 nM) and strong functional activity (EC50 = 0.4 nM). BMS-604992 mimics the action of the endogenous hormone ghrelin, which is known to stimulate growth hormone secretion and increase food intake. Preclinical studies in rodents have demonstrated that the compound effectively stimulates feeding behavior. While it has been extensively used as a pharmacological tool in research to study energy homeostasis and ghrelin signaling, its clinical development status for specific human indications remains largely undocumented or discontinued.

Other names

BMS-604992 hydrochlorideBMS604992 hydrochlorideBMS 604992 hydrochloride