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BMS-770767
- Development stage
- Phase 2
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
BMS-770767 is an investigational small molecule drug developed by Bristol Myers Squibb as an oral inhibitor of the enzyme 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). This enzyme is widely expressed in the liver and other tissues and plays a key role in glucocorticoid metabolism. By inhibiting 11β-HSD1, BMS-770767 was intended to reduce local cortisol production and thereby improve metabolic parameters relevant to conditions such as type 2 diabetes and dyslipidemia. The compound has been studied in clinical trials for hypercholesterolemia (primary hypercholesterolemia/dyslipidemia), but there are no approved indications or known adverse events reported[1][3][5][6][7].
- Other names
- 4-(8-(2-chlorophenoxy)(1,2,4)triazolo(4,3-a)pyridin-3-yl)bicyclo(2.2.1)heptan-1-ol
02
Targets
HSD11B1 (11-beta-hydroxysteroid dehydrogenase type 1)
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