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BMS-914392
- Development stage
- Phase 2
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
BMS-914392 is an investigational oral small molecule drug developed as a potent and selective inhibitor of the Acetylcholine-sensitive potassium channel (IKACh) current. It was designed to specifically target the atria of the heart, aiming to regulate heart contractions and maintain a constant rhythm in patients with atrial fibrillation (AF). The drug acts as a potassium channel blocker, suppressing AF without affecting ventricular refractory periods or heart rate. Clinical studies evaluated its safety, tolerability, and efficacy in reducing AF burden in patients with paroxysmal atrial fibrillation who have pacemakers. While well tolerated, clinical trials did not demonstrate significant reduction in AF episodes compared to placebo[3][4][5][6][8].
- Other names
- BMS-914392BMS914392BMS 914392NTC 801NTC801NTC-801
02
Targets
KACh (G protein–activated inwardly rectifying potassium channel)KCNQ1 (Potassium voltage-gated channel subfamily KQT member 1)
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