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BMS-914392 + metoprolol
- Development stage
- Unknown
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
**BMS-914392 + metoprolol** is a combination of two drugs: BMS-914392, an investigational, potent, selective small molecule inhibitor of the cardiac acetylcholine-dependent potassium current (IKACh), and metoprolol, an approved beta-blocker commonly used for treating hypertension and arrhythmias. The combination has been studied for its effects on the pharmacokinetics of metoprolol and potential drug-drug interaction, especially as an approach to manage atrial fibrillation. BMS-914392 acts by selectively blocking atrial IKACh channels, aiming to suppress atrial arrhythmias with minimal effects on ventricular refractoriness, while metoprolol antagonizes beta-1 adrenergic receptors, reducing heart rate and myocardial contractility[1][9].
- Other names
- BMS-914392 + metoprolol
02
Targets
KACh (G protein–activated inwardly rectifying potassium channel)ADRB1 (β1)
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