Drug intelligence / Profile preview

BMS-963272 + rosuvastatin

Development stage
Unknown
Lead developer
Bristol Myers Squibb
Modality
Small Molecules
Administration
Oral
01

Overview

BMS-963272 + rosuvastatin is a combination of two drugs investigated in clinical studies for potential drug-drug interactions. **BMS-963272** is an orally administered, potent, and selective inhibitor of **MGAT2** (alpha-1,6-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase), developed for the treatment of metabolic disorders such as obesity and nonalcoholic fatty liver disease. **Rosuvastatin** is an HMG-CoA reductase inhibitor (statin) used to lower cholesterol and prevent cardiovascular disease. No fixed-dose commercial combination exists for these two agents; the combination studied here is investigational and was assessed to examine potential pharmacokinetic interactions in healthy participants and their safety and tolerability[1][2][5][7].

02

Targets

MGAT2 (Monoacylglycerol O-acyltransferase 2)HMGCR (3-hydroxy-3-methylglutaryl-coenzyme A reductase)

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