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BMS-986277 is an investigational antibody therapy developed by Bristol Myers Squibb for the treatment of epithelial cancers, specifically advanced epithelial tumors. It was studied as both a monotherapy and in combination with nivolumab (a PD-1 inhibitor) in clinical trials. The drug reached Phase 1/2 clinical development but the program was ultimately terminated and discontinued. The precise mechanism of action for BMS-986277 has not been disclosed or remains unknown, though it is described as an immunotherapy agent and may have involved immune modulation targeting solid tumors[1][2][3][4][5].
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