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BMS-986435
- Development stage
- Phase 2
- Lead developer
- Bristol Myers Squibb
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
BMS-986435 (also known as MYK-224 and HCM-2) is an investigational small molecule drug developed for cardiovascular conditions. It acts as a cardiac myosin modulator and is being studied primarily for the treatment of heart failure with preserved ejection fraction (HFpEF) and hypertrophic cardiomyopathy. The drug aims to improve heart muscle function by modulating the activity of cardiac myosin, potentially offering a novel therapeutic approach distinct from existing treatments that do not target this pathway directly. Clinical trials are ongoing to evaluate its safety, tolerability, pharmacokinetics, and efficacy in both patients with HFpEF and those with symptomatic hypertrophic cardiomyopathy[1][3][4][5].
- Other names
- BMS-986435BMS986435BMS 986435MYK-224MYK224MYK 224HCM-2HCM2HCM 2
02
Targets
MYH7 (Cardiac beta-myosin heavy chain)
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