BMT-121795

BMT-121795 is an **active metabolite** of the oral prodrug BMS-986166, which is a novel, selective sphingosine-1-phosphate receptor 1 (**S1P1R**) modulator. BMT-121795 exhibits **partial agonism** at the S1P1R, leading to receptor modulation with a potentially favorable safety profile compared to full S1P receptor agonists. The unique S1P1R pharmacology of BMT-121795 is being investigated for immunomodulatory therapy, likely in the context of autoimmune and inflammatory diseases. It is not developed or marketed as an independent clinical drug, but rather studied as the major circulating, active metabolite responsible for the effects of its prodrug. Studies are focused on the **pharmacokinetics, safety, and drug-drug interaction profile** of BMT-121795 in healthy subjects and in combination with other agents[1][3][5][7][8][9].

Other names

BMT-121795BMT121795BMT 121795