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BN108
- Development stage
- Discontinued
- Lead developer
- Bionovo
- Modality
- Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
- Administration
- Oral
01
Overview
BN108 is an orally administered botanical extract derived from the plant *Anemarrhena asphodeloides*, developed by Bionovo for the treatment of breast cancer. The drug's primary active constituent responsible for its cytotoxic activity is timosaponin AIII (TAIII), a steroidal saponin of the coprostane type. BN108 induces cancer cell death through two distinct pro-apoptotic pathways: the rapid inactivation of the AKT and mTOR (specifically mTORC1) signaling pathways and the induction of endoplasmic reticulum (ER) stress. It was designed as a targeted anticancer compound with selective cytotoxicity, aiming to spare normal cells and potentially offer better tolerability than conventional chemotherapy.
- Other names
- Anemarrhena asphodeloides extract
02
Targets
AKT (RAC-alpha serine/threonine-protein kinase)Mechanistic target of rapamycin complex 1
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