BN82002

**BN82002** is a potent, selective, and irreversible small molecule inhibitor of the CDC25 family of phosphatases (CDC25A, CDC25B, and CDC25C), which play key roles in cell cycle regulation by dephosphorylating CDK-cyclin complexes to promote G1/S and G2/M transitions. It exhibits antitumor activity by impairing proliferation of human tumor cell lines in vitro and inhibiting tumor growth in vivo, and demonstrates anti-inflammatory effects by dose-dependently suppressing LPS-induced production of nitric oxide, prostaglandin E2, TNF-α, iNOS, and COX-2 in macrophages via specific inhibition of AKT2 at Tyr-178, thereby blocking NF-κB nuclear translocation and signaling without affecting AKT1 or IKKβ. Preclinical studies also show protection against tissue damage and improved survival in septic mouse models through AKT2-NF-κB pathway modulation.[1][4][6][7][12][13]