Clinical trials
Follow clinical development from study design and recruitment through results.
- Trial phase
- Status
- Readouts
Drug intelligence / Profile preview
BNN27
- Development stage
- Preclinical
- Lead developer
- Foundation for Research and Technology - Hellas
- Modality
- Small Molecules
- Administration
- Intraperitoneal
01
Overview
BNN27 is a synthetic small molecule classified as a C17-spiroepoxy derivative of the neurosteroid dehydroepiandrosterone (DHEA). It is designated a "microneurotrophin" due to its capacity to mimic some neurotrophin functions through direct and selective modulation of neurotrophin receptors, specifically nerve growth factor (NGF) receptors TrkA and p75NTR. BNN27 demonstrates neuroprotective, anti-apoptotic, anti-inflammatory, and anxiolytic effects in preclinical models. It is notable for lacking classical steroidogenic activity while retaining potent neurotrophic signaling, making it a lead molecule for potential therapies targeting neurodegenerative and inflammatory diseases, retinal disorders (such as diabetic retinopathy), cognitive impairment, pain, and spinal cord injury[1][2][3][4][5][6][7][8].
- Other names
- BNN27BNN-27BNN 27(R)-3β,21-dihydroxy-17R,20-epoxy-5-pregnene17-spiroepoxy-DHEA derivative
02
Targets
NTRK1 (Tropomyosin-related receptor kinase A)NGFR (p75NTR)
Beyond the preview
Go deeper on BNN27.
Explore the evidence, development activity, and competitive landscape with Gosset’s full data platform.
Indications & development
Explore development by indication, patient population, and geography.
- Indications
- Development status
- Countries
Licensing & deals
Trace asset ownership, licensing agreements, and commercial partnerships.
- Partners
- Deal terms
- Milestones
Patents & exclusivity
Explore the patent landscape and regulatory exclusivity around an asset.
- Patents
- Expiration dates
- Exclusivity
Competitive landscape
Compare development programs by target, modality, and indication.
- Competing assets
- Targets
- Development stage
Research & analysis
Connect source evidence and development news to your research questions.
- Publications
- News
- Analysis
Bring the full picture into focus.
See how Gosset can support your research on BNN27.