Drug intelligence / Profile preview

BOL-DP-o-04

Development stage
Phase 2
Lead developer
BOL Pharma
Modality
Orthosteric Ligands → Classical Binding Small Molecules → Small Molecules, Peptides, Recombinant Proteins and Enzymes
Administration
Sublingual
01

Overview

BOL-DP-o-04 is a sublingual formulation of medical cannabis developed by Breath of Life (BOL) Pharma for the treatment of pain, including pain associated with diabetic neuropathy and chronic pain in patients undergoing hemodialysis. It is classified as an analgesic and cannabinoid. The drug acts as a **cannabinoid receptor modulator**, containing both trans-delta-9-tetrahydrocannabinol (THC) and cannabidiol (CBD) in a 1:6 ratio. Clinical studies have shown that short-term use was generally well tolerated in patients with end-stage kidney disease on hemodialysis, with most adverse events being mild to moderate and resolving spontaneously[1][3][5]. The product is not considered a new molecular entity.

Other names
BOL-DP-o-04 + SCOBOL-DP-o-04 + SOC
02

Targets

CNR1 (Cannabinoid receptor 1)TRPV1 (Transient receptor potential cation channel subfamily V member 1)HTR1A (Serotonin receptor 1A (5-hydroxytryptamine receptor 1A))

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