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BOLD-300
- Development stage
- Preclinical
- Lead developer
- Bold Therapeutics
- Modality
- Covalent Small Molecules → Small Molecules, DNA Intercalators/Alkylators → Nucleic Acid-Directed Small Molecules → Small Molecules, Light/Condition-Responsive Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules
- Administration
- Intramuscular
01
Overview
BOLD-300 is an early-stage drug candidate being developed by Bold Therapeutics as part of its pipeline of metallotherapeutics. Bold Therapeutics focuses on the development of metal-based small molecules designed to treat advanced cancers that are resistant to standard therapies. While BOLD-300's specific molecular target and primary clinical indications have not been publicly disclosed in detail, it is part of a broader platform of ruthenium-based or other metal-based compounds that follow the company's lead candidate, BOLD-100 (a GRP78 inhibitor). The agent is being positioned within the company's oncology portfolio for the treatment of solid tumors.
02
Targets
GRP78 (78 kDa glucose-regulated protein)RK (Ribokinase)
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