boldine

Boldine is a natural aporphine alkaloid primarily derived from the leaves and bark of the boldo tree (*Peumus boldus*). Developed as an active pharmaceutical ingredient (API) by Aktin Pharmaceuticals, it is being investigated for its potential in treating schizophrenia. Mechanistically, boldine acts as an antagonist at dopamine D1 and D2 receptors, which underlies its antipsychotic-like properties observed in preclinical models. Beyond its dopaminergic activity, boldine is recognized as a potent antioxidant and free radical scavenger, offering neuroprotective benefits by reducing oxidative stress and lipid peroxidation, which are often implicated in the pathophysiology of neuropsychiatric and neurodegenerative disorders.

Other names

波尔定碱(S)-Boldine1,10-Dimethoxy-6-methyl-4,5,6,6a-tetrahydro-4H-dibenzo[de,g]quinoline-2,9-diolBoldina