bone marrow concentrate

Bone marrow concentrate (BMC) is an autologous biologic product derived from a patient's own bone marrow, typically harvested from the iliac crest or tibia. It contains a heterogeneous population of cells, including mesenchymal stem cells (MSCs), hematopoietic stem cells, and a variety of bioactive molecules such as growth factors and cytokines. In the context of knee osteoarthritis, BMC is utilized for its immunomodulatory and trophic properties, which aim to restore joint homeostasis and reduce the inflammatory environment associated with cartilage degeneration. The specific protocol developed by Istituto Clinico Humanitas involves a dual-delivery approach: intra-articular injection to address cartilage and synovial tissues, and subchondral bone injection to target bone marrow edema and subchondral bone damage, which are significant drivers of osteoarthritis progression and pain.

Other names

Bone Marrow Concentrateautologous bone marrow concentrate