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bone marrow-derived human mesenchymal stem cells
- Development stage
- Preclinical
- Lead developer
- Xpand Biotechnology
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intraarticular
01
Overview
Bone marrow-derived human mesenchymal stem cells (BM-hMSCs) is an autologous cell therapy product being developed by Xpand Biotechnology BV, a Dutch company specializing in cell expansion technologies. The therapy involves the ex vivo expansion of a patient's own mesenchymal stem cells, harvested from bone marrow, using a closed-system bioreactor to ensure manufacturing consistency and scalability. These cells are intended for the treatment of hip osteoarthritis, where they are hypothesized to exert therapeutic effects through chondroprotective and immunomodulatory mechanisms. Specifically, the MSCs can differentiate into chondrocytes and produce extracellular matrix molecules, potentially regenerating damaged articular cartilage and modulating the inflammatory environment within the joint.
- Other names
- autologous bone marrow-derived mesenchymal stem cellsBM-MSCs
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