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bone marrow-derived mesenchymal stem cells (Sun Yat-sen University)

Development stage: Unknown
Lead developer: Sun Yat-sen University
Modality: Stem Cell Therapies → Cell Therapies
Administration: Intravenous

Overview

Investigational cell therapy consisting of bone marrow-derived mesenchymal stem cells (BMSCs) developed by Sun Yat-sen University for the treatment of pediatric idiopathic pulmonary hemosiderosis (IPH). These cells exert immunomodulatory effects by increasing the population of CD4+ CD25+ regulatory T cells and decreasing Th17 cells, thereby reducing alveolar capillary hemorrhage and promoting tissue repair. In clinical studies, it has been evaluated as a maintenance therapy in combination with corticosteroids and leflunomide to prevent recurrence and progression to pulmonary fibrosis in children with refractory IPH.

Other names: BMSCBMSCsbone marrow mesenchymal stem cells

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