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bone marrow-derived mesenchymal stem cells + hyaluronic acid
- Development stage
- Unknown
- Lead developer
- Clínica Universidad de Navarra
- Modality
- Biodegradable Polymers → Polymer-based Nanoparticles → Nanoparticles → Drug Delivery Systems, Stem Cell Therapies → Cell Therapies
- Administration
- Intraarticular
01
Overview
**Bone marrow-derived mesenchymal stem cells + hyaluronic acid** is an investigational combination therapy consisting of autologous or allogeneic bone marrow-derived mesenchymal stem cells (BM-MSCs) and hyaluronic acid (HA), typically administered by intra-articular injection for the treatment of joint disorders such as osteoarthritis. **BM-MSCs** are multipotent stromal cells capable of modulating immune responses, exerting anti-inflammatory effects, stimulating tissue repair, and differentiating into chondrocytes, contributing to cartilage regeneration. **Hyaluronic acid** acts as a viscosupplement, providing lubrication, reducing inflammation, and supporting chondrogenesis by enhancing the viability and proliferation of BM-MSCs. The combination is under investigation in preclinical and clinical studies for its potential to synergistically improve outcomes in articular cartilage repair and osteoarthritis by leveraging both regenerative (cellular) and lubricating/structural (HA) mechanisms[1][2][3].
- Other names
- BM-MSCs + hyaluronic acidBMSCs + HA
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