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bone marrow mesenchymal stem cells
- Development stage
- Phase 3
- Lead developer
- Catholic University of Santiago de Guayaquil
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intraarticular
01
Overview
Bone marrow mesenchymal stem cells (BM-MSCs) are multipotent stromal cells harvested from a patient's own bone marrow. In this specific application by the Universidad Catolica Santiago de Guayaquil, the cells are used as an autologous intra-articular injection for the treatment of Grade II-III knee osteoarthritis. BM-MSCs function through immunomodulatory and trophic effects, secreting various cytokines and growth factors that reduce joint inflammation and potentially facilitate cartilage repair. The therapy is currently being evaluated in a Phase 3 clinical trial to compare its efficacy against adipose-derived stem cells and a combined cell population.
- Other names
- BM-MSCautologous bone marrow mesenchymal stem cells
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