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bone marrow mesenchymal stem cells + adipose mesenchymal stem cells
- Development stage
- Phase 3
- Lead developer
- Royan Institute
- Modality
- Stem Cell Therapies → Cell Therapies
- Administration
- Intraarticular, Intralesional, Intravenous
01
Overview
A combination therapy using mesenchymal stem cells derived from both bone marrow (BM-MSCs) and adipose tissue (AD-MSCs/AT-MSCs). This combination has shown synergistic effects in bone repair and regeneration, with enhanced results when BM-MSCs are injected prior to AT-MSCs[1]. The therapy leverages the complementary properties of both cell types - BM-MSCs having stronger osteogenic potential and AT-MSCs being easier to harvest with higher yields[2]. It is being investigated for treating bone defects[1], osteoarthritis[3], and potentially enhancing radiotherapy effects in hepatocellular carcinoma[5].
- Other names
- BM-MSCs + AD-MSCsBM-MSCs + AT-MSCsbone marrow MSCs + adipose MSCs
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