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bone morphogenetic protein 10
- Development stage
- Preclinical
- Lead developer
- Taipei Veterans General Hospital
- Modality
- Recombinant Proteins and Enzymes
- Administration
- Intraperitoneal
01
Overview
Bone morphogenetic protein 10 (BMP10) is a member of the TGF-β superfamily, primarily synthesized in the right atrium and secreted into the systemic circulation. It plays a critical role in cardiac development and the maintenance of postnatal cardiac function. Recent research, such as that presented at ATS 2026, suggests that recombinant BMP10 may have therapeutic potential in treating pulmonary fibrosis. It appears to mitigate fibrotic progression by suppressing epithelial-mesenchymal transition (EMT), endothelial-mesenchymal transition (EndoMT), and fibroblast-to-myofibroblast differentiation (FMD), likely through the inhibition of the TGF-β/Smad2 signaling pathway.
- Other names
- BMP-10BMP10BMP 10
02
Targets
ACVR2A (Activin receptor type 2A)ACVR2B (Activin receptor type IIB)ACVRL1 (Activin receptor-like kinase 1)BMPR1ABMPR1BBMPR2 (Bone morphogenetic protein receptor type II)ENG (Integrin Beta 6)BMPR (Bone morphogenetic protein receptor)SMAD2 (Mothers against decapentaplegic homolog 2)TGFB (GARP–latent transforming growth factor beta 1 complex)
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