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borapetol B
- Development stage
- Preclinical
- Lead developer
- Institute for Medical Research
- Modality
- Small Molecules
- Administration
- Oral
01
Overview
Borapetol B is a cis-clerodane-type furanoditerpenoid aglycone isolated from the stems of the medicinal plant *Tinospora crispa* (and *Tinospora tuberculata*). It exhibits anti-diabetic properties primarily by stimulating insulin release from pancreatic beta-cells. Preclinical studies in normoglycemic Wistar and spontaneously diabetic Goto-Kakizaki (GK) rats have demonstrated that oral administration of borapetol B significantly improves blood glucose levels and increases plasma insulin levels. Its mechanism of action involves the activation of L-type voltage-dependent calcium channels and is partly dependent on the closure of ATP-sensitive potassium (K-ATP) channels and G-protein-coupled exocytosis, without causing cellular damage or leakage.
- Other names
- compound 1compound1compound-1
02
Targets
KATP channel (ATP-sensitive potassium channel)CACNA1C (Voltage-dependent L-type calcium channel subunit alpha-1C)
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