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bordetella pertussis whole cell vaccine
- Development stage
- Unknown
- Lead developer
- NEC
- Modality
- Vaccines & Immunotherapeutics
- Administration
- Intradermal
01
Overview
Bordetella pertussis whole cell vaccine is an inactivated bacterial vaccine traditionally used for the prevention of pertussis (whooping cough). In the context of oncology, it is being investigated as a potent immunological adjuvant due to its high content of pathogen-associated molecular patterns (PAMPs), such as lipopolysaccharide (LPS) and lipoproteins, which act as ligands for various Toll-like receptors (TLRs). By stimulating TLRs (primarily TLR2 and TLR4), the vaccine promotes the maturation of dendritic cells and the secretion of pro-inflammatory cytokines, thereby enhancing the cellular immune response against co-administered tumor-associated antigens. NEC Corporation is evaluating this vaccine in combination with a WT1 peptide (W10) for the treatment of castration-resistant prostate cancer in Japan, aiming to leverage its adjuvant properties to stimulate antitumor immunity.
- Other names
- inactivated Bordetella pertussis whole cell vaccinewP vaccinepertussis whole cell vaccine
02
Targets
TLR4 (Toll-like receptor 4)TLR2 (Toll-like Receptor 2)
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