Drug intelligence / Profile preview

Borraginol Premium

Development stage
Unknown
Lead developer
Amato Pharmaceutical Products
Modality
Small Molecules
Administration
Rectal, Topical
01

Overview

Borraginol Premium is an approved over-the-counter (OTC) hemorrhoid treatment developed by Amato Pharmaceutical Products (a subsidiary of Rohto Pharmaceutical). It is classified as a Category 2 (Designated Class 2) OTC drug in Japan and is available in multiple formulations, including an ointment, prefilled disposable applicators, and suppositories. The product is administered rectally or topically to relieve pain, bleeding, swelling, and itching associated with painful hemorrhoids. Borraginol Premium is a multi-ingredient combination therapy containing prednisolone acetate (a corticosteroid targeting glucocorticoid receptors to suppress inflammation), lidocaine (a local anesthetic targeting sodium channels for pain relief), chlorpheniramine maleate (an antihistamine targeting histamine H1 receptors to relieve itching), allantoin (to promote wound healing), tocopherol acetate (to improve peripheral blood circulation), and other supportive active ingredients such as isopropyl methylphenol (an antiseptic) or glycyrrhetinic acid (an anti-inflammatory agent), depending on the specific formulation.

Brand names
BORRAGINOL® PREMIUMBorraginol PremiumBorraginol Premium Injection OintmentBorraginol Premium OintmentBorraginol Premium Suppositories
Other names
ボラギノールプレミアムボラギノールプレミアム坐剤ボラギノールプレミアム注入軟膏ボラギノールプレミアム軟膏
02

Targets

GR (Glucocorticoid receptor)HRH1 (Histamine H1 Receptor)NaV (Voltage-gated sodium channels)

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