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Drug intelligence / Profile preview
bortezomib + tositumomab
- Development stage
- Phase 1
- Lead developer
- Takeda
- Modality
- Antibody-Radionuclide Conjugates → Antibody Conjugates → Antibody-Based Therapeutics, Monoclonal Antibodies → Antibody-Based Therapeutics, Small Molecules
- Administration
- Intravenous, Subcutaneous
01
Overview
Bortezomib + tositumomab is a combination of two anticancer agents with distinct mechanisms of action. Bortezomib is a small molecule proteasome inhibitor that blocks the 26S proteasome, leading to disruption of protein degradation and induction of apoptosis in cancer cells. It is primarily used for multiple myeloma and mantle cell lymphoma. Tositumomab is a murine monoclonal antibody targeting the CD20 antigen on B-cells, often conjugated with radioactive iodine (Iodine 131) to deliver targeted radiation therapy; it was developed for the treatment of B-cell non-Hodgkin's lymphoma. The combination would theoretically provide both direct cytotoxicity via proteasome inhibition and targeted immunotherapy/radioimmunotherapy against malignant B-cells[1][2][3][6].
- Brand names
- BEXXAR
- Other names
- Iodine I 131 tositumomab
02
Targets
CD20 (B-lymphocyte antigen CD20)PSMB9 (Immunoproteasome subunit beta type-1i)PSMB1 (26S Proteasome (β1-Subunit))PSMB5 (Proteasome subunit beta Type-5)
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