Drug intelligence / Profile preview

bosakitug

Development stage
Phase 3
Lead developer
Aclaris Therapeutics
Modality
IgG Antibodies → Naked Antibodies → Monoclonal Antibodies → Antibody-Based Therapeutics, Recombinant Proteins and Enzymes
Administration
Subcutaneous
01

Overview

Bosakitug is a humanized monoclonal antibody that targets thymic stromal lymphopoietin (TSLP), a cytokine known as a master regulator of type 2 (Th2) inflammation. By inhibiting TSLP, bosakitug aims to reduce inflammatory responses associated with diseases such as atopic dermatitis (atopic eczema), asthma, chronic obstructive pulmonary disease (COPD), and chronic rhinosinusitis with nasal polyps. The drug is administered subcutaneously and was developed using Biosion’s H3 antibody platform and SynAb technology. Bosakitug has demonstrated high affinity and potency in neutralizing TSLP in preclinical studies and early clinical trials. It is currently in phase 2 or phase 3 clinical development for several indications[1][3][4][5][6].

Other names
anti-TSLP mAb
02

Targets

TSLP (Thymic stromal lymphopoietin)

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