Drug intelligence / Profile preview

Boscox

Development stage
Unknown
Lead developer
Guangzhou Haicheng Pharmaceutical
Modality
Metabolically Activated Prodrugs → Prodrugs/Conditional Activator Small Molecules → Small Molecules, Classical Binding Small Molecules → Small Molecules
Administration
Oral
01

Overview

Boscox is a 100% natural botanical extract developed as an anticoccidial feed additive for livestock and poultry. Its active ingredients, Terminalia gallic acid and costunolide, are extracted from Chinese herbal medicine. Boscox works by selectively inhibiting dihydroorotate dehydrogenase (DHODH), a key enzyme in de novo pyrimidine synthesis and nucleotide metabolism of coccidia. This inhibition disables the coccidia during their endogenous developmental stages, including sporozoite, schizogony, and gametogony. Boscox is used to prevent and treat coccidiosis caused by various Eimeria species (such as E. tenella, E. necatrix, E. acervulina, E. maxima, and E. brunetti) in chickens, Isospora coccidiosis in swine, and E. stiedai in rabbits. Additionally, it helps reduce necrotic enteritis caused by Clostridium perfringens and promotes intestinal repair.

Brand names
Boscox
02

Targets

DHODH (Coccidial dihydroorotate dehydrogenase)

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