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bothrops antivenom
- Development stage
- Phase 2
- Lead developer
- Instituto Butantan
- Modality
- Antibody-Based Therapeutics
- Administration
- Intravenous
01
Overview
Bothrops antivenom (specifically referring to the freeze-dried trivalent antivenom, FDTAV) is a lyophilized biologic antivenom developed jointly by the Instituto de Biologia do Exército (Army Institute of Biology) and the Instituto Butantan in Brazil. It consists of F(ab')₂ fragments of equine immunoglobulin-based antibodies raised against the venoms of Bothrops, Lachesis, and Crotalus snake species. Designed to overcome the cold-chain storage limitations of standard liquid antivenoms, FDTAV can be stored at room temperature, making it highly suitable for remote tropical regions like the Amazon. It has been evaluated in a Phase IIb clinical trial in the Brazilian Amazon, demonstrating comparable safety and efficacy to standard liquid antivenoms in treating mild to moderate envenomings from these snake genera.
- Other names
- freeze-dried trivalent antivenomFDTAVFDTAsoro antibotrópicoantibothropic antivenom
02
Targets
SVMPs (Bothrops snake venom metalloproteinases)Bothrops venom phospholipase A2SVSP (Snake venom serine protease)Lachesis venom toxinsBothrops venomLMV (Lachesis muta venom)PLA2 (Phospholipase A2 group IID)SVMP (Snake venom metalloproteinase)
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