Botox Cosmetic or Dysport-The Maas Clinic-lateral orbital rhytids

This refers to a comparative clinical study conducted by The Maas Clinic evaluating two distinct botulinum toxin type A products: Botox Cosmetic (onabotulinumtoxinA) and Dysport (abobotulinumtoxinA). Both are biologic neuromodulators used for the temporary improvement in the appearance of moderate to severe lateral orbital rhytids (crow's feet). They share a common mechanism of action: the heavy chain of the toxin binds to neuronal surfaces, while the light chain acts as a zinc-dependent endopeptidase that cleaves SNAP-25 (Synaptosomal-associated protein 25). This cleavage prevents the formation of the SNARE complex, thereby blocking the release of the neurotransmitter acetylcholine at the neuromuscular junction, leading to localized muscle relaxation. The Maas Clinic study was a randomized, double-blind, split-face Phase 4 trial designed to compare the efficacy, onset, and duration of these two specific formulations.

Brand names

Botox CosmeticDysport

Other names

onabotulinumtoxinAabobotulinumtoxinABotoxReloxinAzzalure