botulinum toxin type A haemagglutinin complex

**Botulinum toxin type A haemagglutinin complex** is a purified botulinum neurotoxin type A product presented as a toxin-haemagglutinin complex derived from *Clostridium botulinum*. After local injection, the neurotoxin enters cholinergic nerve terminals and cleaves SNAP-25, thereby blocking acetylcholine release at the neuromuscular junction and producing a temporary, localized chemodenervation and muscle relaxation. This pharmacology underlies established aesthetic and neurologic uses of botulinum toxin type A haemagglutinin-containing products such as Dysport, and also investigational surgical applications in which abdominal wall muscle paralysis may facilitate midline fascial closure. In the context provided here, Hospital Universitario La Paz is developing early botulinum toxin administration for **open abdomen** management, where the intended effect is reduction of lateral abdominal wall tension to improve primary closure rates.

Brand names

Dysport

Other names

clostridium botulinum type A toxin-haemagglutinin complexclostridium botulinum toxin type A haemagglutinin complexbotulinum toxin Abotulinum neurotoxin type A haemagglutinin complex